Patterning DNA Origami on Membranes Through Protein Self-Organization

Abstract Spatial organization on the atomic scale is one of key objectives nanotechnology. The development DNA nanotechnology a hallmark material programmability in 2D and 3D, which large variety available modifications allows it to be interfaced with number inorganic organic materials. Nature’s solution spatiotemporal control has been evolution self-organizing protein systems capable pattern formation through energy dissipation. Here, we show that combining origami minimal micron-scale pattern-forming system vastly expands applicability nanotechnology, whether for biocompatible materials or as an essential step toward building synthetic cells from bottom up. We first describe interaction nanostructures model lipid membranes introduce MinDE Escherichia coli . then outline how used elucidate diffusiophoresis formation. this novel biological transport mechanism can, turn, harnessed micron membranes. Finally, discuss our approach could create next generation hybrid materials, cargo delivery multiscale molecular patterning capabilities.